NKX2-1 anticorps

N° du produit ABIN6297613

Cet anticorps Souris Monoclonal détecte spécifiquement NKX2-1 dans IHC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour NKX2-1 anticorps (ABIN6297613)

Antigène: NKX2-1 (NK2 Homeobox 1 (NKX2-1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NKX2-1 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-NKX2-1 anticorps

Fonction: Mouse anti-Human/Mouse/Rat TTF1 Antibody [IHC only]

Specificité: Nuclear

Purification: Recombinant protein was used as the immunogen for the TTF1 antibody.

Immunogène: Recombinant protein was used as the immunogen for the TTF1 antibody.

Information d'application

Indications d'application: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Stockage

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur NKX2-1

Antigène: NKX2-1 (NK2 Homeobox 1 (NKX2-1))

Autre désignation: Homeobox protein Nkx-2.1

Sujet:

Target Description: Recognizes a protein of 40 kDa, identified as Thyroid transcription factor-1. TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

Gene Symbol: NKX2-1///NKX2A///TITF1///TTF1

ID gène: 7080

UniProt: P43699

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Glucan Metabolic Process, Feeding Behaviour